Methylation – B12 therapy & 23andMe Genetic test


So, I had been on ‘armor’ thyroid for months and decided I needed a specialist who wasn’t my allopathic endocrinologist who would listen to me and actually help (with chronic fatigue, brain fog, bad digestion, low metabolic rate (i.e. low body temperature) and low testosterone) so I searched and searched and found Marek Doyle from Blueprint Fitness.

He seemed to really know his sh1t! I read his site inside and out and he seemed to know all the secrets I had found out to date and more. I had to meet him too!

When I first met him we ran through a whole bunch of questions and at the end of it he put a plan together for me.

You can see the full protocol for each, by following the links below.

His thoughts were:

  • I had a genetic mutation that I needed to be checked for (with 23andme) – protocol below
  • I had candida (already knew that) that needed treating (add link to Candida page)
  • I had adrenal fatigue (add link to fatigue page)

Genetic Mutations & Methylation

Essentially my results showed I had the MTHFR genetic mutation which meant my liver doesn’t detox properly and by supplementing correctly I could sort it out. This meant toxins like Mercury would leave my body more naturally than Chelation and mean that I wouldn’t get sick so easily.

Methylation is a very big subject and I have Eric from to thank for putting together his AWESOME posts as guidance. Unfortunately he didn’t simplify the protocol so I will shortly.

Eric’s pages are (enjoy!):

Now, every time I’ve had blood tests for B12 and Folate in the past it’s always shown high. Why? My genetics (and symptoms) says I’m deficient!

I started researching and found this article, which essentially says that if you lack Glutathione your B12 is vulnerable to attack and if your B12 isn’t right you can’t make Glutathione! Circular or what!

Lithium and Methylation

Around the same time I had my one year follow up hair mineral analysis test come back showing me how my heavy metal levels had dropped – and one thing that didn’t move was Lithium. I was completely out. Nothing, nada, nil. My father is bi-polar so seeing lithium low (still) worried me, so I started researching the connection to Mercury (and just by chance B12 too!) It turns out that if you don’t have enough lithium your B12 doesn’t go into your cells, leaving you B12 deficient…! BOOM!

Low White Blood Cell Count & Lithium

What is really strange is that week I had a blood test done and my White Blood Cell Count was at it’s lowest ever, 2.9 on a scale of 3 to 8. This worried me – and I remembered Andy Cutler (in The Amalgam illness book) said to take lithium orotate to help boost Neutrophils and WBC. It was coming together nicely.

After a week on Lithium (the only other thing I had changed was adding in Red Reishi mushroom supplement which gave me headaches and bad guts) I had my blood tested again (by chance) and suddenly my WBC count was up to 6.3! – now that’s a stronger immune system. In a week! My doctor couldn’t believe it.

Methylation (and my protocol)

Marek started me on TMG for a week (to open up the methylation pathways), then told me to add in 1 B-right multi-b (which gave my body a tiny bit of B12 and folate), followed by Hydroxcobalamin a week later. Now most places say don’t bother with Hydroxo as your liver might not convert it to the active forms of B12 (such as Methylcobalamin and Adenosylcobalamin) but Marek thought differently due to my mutations. It also gives your body a chance to kick back into action.

His analogy was “imagine you have an old car, and you put your foot flat on the accelerator. It was fall apart. Now, if you slowly build up speed it will be a lot more stable. Now that’s what we’re doing with you”.

Essentially, starting with an active B12 can put your detoxification pathways under too much pressure causing you to get ill (die-off), so starting like that is fine, but you must progress to active B12 soon.

If you want the full details the source is:

Fredds protocol from Pheonixrising is tough to unravel for a layman, and took me a while to figure it out, but essentially it is

  1. Start with Swanson TMG 500mg half a day for a week (This opens up the methylation pathways)
  2. Then raise to 1 tablet a day of the above,
    then start:
  3. 1 jarrow b-right a day for 2 weeks, then raise to 2 a day.
    After 2 more weeks start:
  4. 200mcg of Solgar methylfolate a day for a week
  5. Then half of a Jarrow Methylcobalamin 1000mg for 2 weeks (in the mouth under your lip for 45 minutes)
    Then raise:
  6. Methylfolate to 400mcg/day for 2 weeks (and raise by 200mcg (half a tablet extra) a fortnight until you reach 800mcg a day)
  7. Then raise to 1 whole Jarrow 1000mg Methylcobalamin
  8. Take temperatures and see if it’s 37c if not introduce Adenosylcobalamin at 1/4 of a 3000mg tablet
To be continued and updated soon…

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